>  Institute  >  Staff  >  Natalia N. Bezborodkina

Natalia N. Bezborodkina
Web of Science ResearcherID: https://www.webofscience.com/wos/author/record/AAY-4169-2020
Scopus Author ID: https://www.scopus.com/authid/detail.uri?authorId=6603056372
RSCI: https://www.elibrary.ru/author_profile.asp?authorid=89486
ORCID ID: https://orcid.org/0000-0002-7435-742X
Google Scholar: https://scholar.google.com/citations?user=LmrnjuoAAAAJ
Academic degree: Doctor of Biological Sciences
Position: Scientific Secretary
E-mail: Natalia.Bezborodkina@zin.ru
Contact phone: +7 (812) 328-03-11
Educational background:
  • 2006: Candidate Degree (Ph.D.), Institute of Cytology of Russian Academy of Sciences;
  • 1997: Master of Science in Biology, St. Petersburg State University.
Dissertations:
  • “Comparative analysis of glycogen metabolism in hepatocytes of normal and cirrhotic liver” (PhD)
  • “Characteristics of glycogenesis in hepatocytes during chronic liver diseases” (PhD habilitation)
Research interests: Сell biology, biochemistry, cytofluorimetry, carbohydrate metabolism in the liver of mammals in normal and pathological conditions, cellular mechanisms of glycogenesis, the spatial structure of glycogen molecules in hepatocytes.
Professional membership:
  • Member of Scientific Council of the Institute of Cytology of Russian Academy of Sciences;
  • Scientific Secretary of the Organizing committee of the Conference with international participation “Cell Biology: Problems and Prospects”;
  • Scientific Secretary of the Organizing committee of the II Russian Conference “Intracellular signaling, transport, cytoskeleton”;
  • Scientific Secretary of the Organizing committee of the XVII and XVIII Russian Symposiums “Structure and functions of the cell nucleus”;
  • Member of the Organizing committee of the Russian Symposium and School-Conference for Young Scientists for Cell Biology in Culture;
  • Scientific Secretary of the Scientific Council on Cell Biology and Immunology of the Russian Academy of Sciences;
  • Member of the Organizing committee of the III Congress of Cell Biology Society;
  • Member of the Russian Society of Biochemists and Molecular Biologists at the Russian Academy of Sciences.
Teaching and expertise:
  • 2013-2019: Head of Graduate School at the Institute of Cytology of Russian Academy of Sciences;
  • 2019: Scientific Secretary of the Dissertation Council at the Institute of Cytology of Russian Academy of Sciences;
  • Supervisor of 7 bachelor's and 6 master's theses, 1 candidate dissertation.
Scientific projects and grants:
  • Personal grants M01-2.6K-593 and M00-2.6K-401 of the St. Petersburg competition for students, graduate students, young scientists and specialists in the field of humanitarian, natural, technical and medical sciences.
  • Head of RFBR grants No. 02-04-06714-mas, 03-04-06681-mas, 08-04-00971-a.
  • Contractor in grants from the Russian Foundation for Basic Research No. 01-04-49115-a, 06-04-48439-a, 14-04-00730-a and the Russian Science Foundation No. 14-50-00068, Grants of the Presidium of the St. Petersburg Scientific Center of the Russian Academy of Sciences (2008 and 2009)
Selected Publications:
  • Kudryavtseva M.V, Emelyanov A.V, Sakuta G.A., Bezborodkina N.N., Kudryavtsev B.N. 1998. Glycogen-forming function of hepatocytes in the rat regenerating cirrhotic liver after a partial hepatectomy. Tissue and Cell. 30 (2):1-7.
    https://doi.org/10.1016/S0040-8166(98)80074-8
  • Kudryavtseva M.V., Bezborodkina N.N., Kudryavtsev B.N. 1999. Restoration of the glycogen-forming function of hepatocytes in rats with liver cirrhosis is facilitated by a high-carbohydrate diet. Brit.J.Nutrition. 81(6): 473-480.
    https://doi.org/10.1017/S0007114599000835
  • Кудрявцева М.В., Безбородкина Н.Н., Сек Е.Н., Шапиро И.Я., Барановский А.Ю., Кудрявцев Б. Н. 2000. Влияние препарата “Вилон” на гликогенообразовательную функцию гепатоцитов при экспериментальном циррозе печени у крыс. Цитология. 42 (8): 757-763.
  • Kudryavtseva M. V., Bezborodkina N.N., Kudryavtsev B. N.  2001. Glycogen-forming function of hepatocytes in cirrhotically altered rat liver after treatment the chorionic gonadotropin. Exp. Toxic. Pathol. 53 (1): 57-63.
    https://doi.org/10.1078/0940-2993-00155
  • Kudryavtseva M. V., Bezborodkina N. N., Radchenko V. G., Okovity S. V., Kudryavtsev B. N. 2001. Metabolic heterogeneity of glycogen hepatocytes of patients with liver cirrhosis. Europ. J. Gastroenterol. and  Hepatol. 13 (6): 693-697.
    https://doi.org/10.1097/00042737-200106000-00013
  • Кудрявцева М.В., Безбородкина Н.Н., Оковитый С.В., Иванова О.В., Кудрявцев Б.Н. 2002. Особенности влияния бемитила на метаболизм гликогена в гепатоцитах патологически измененной печени человека. Цитология.  44 (7): 668-675.
  • Bezborodkina N., Kudryavtseva M., Kudryavtsev B. 2002. Analysis of the activity of key glycogen metabolism enzymes after a partial hepatectomy of normal and cirrhotic rat liver. Proc. Georgian Acad. Sci., Biol. Ser. A. 28(S):1-5.
  • Kudryavtseva M.V., Bezborodkina N.N., Okovity S.V., Kudryavtsev B.N. 2003. Effects of the 2-ethylthiobenzimidazole hydrobromide (bemithyl) on carbohydrate metabolism in cirrhotic rat liver. Exp. Toxic. Pathol. 54 (4): 339-347.
    https://doi.org/10.1078/0940-2993-00270
  • Безбородкина Н.Н., Кудрявцева М.В., Оковитый С.В., Нилова В.Л., Кудрявцев Б.Н. 2003. Динамика содержания гликогена в нормальной и цирротически измененной печени после введения глюкозы голодным крысам. Цитология. 45 (10): 1019-1026.
  • Оковитый С.В., Безбородкина Н.Н., Зарубина И.В., Миронова О.П., Кудрявцев Б.Н., Шуленин С.Н. 2006. Исследование гепатопротекторного эффекта бемитила на модели длительного токсического поражения печени. Экспериментальная и клиническая фармакология 69(2): 52-54.
  • Безбородкина Н.Н., Оковитый С.В., Кудрявцева М.В., Кирик О.В., Зарубина И.В., Кудрявцев Б.Н. 2008. Морфометрия митохондриального аппарата гепатоцитов нормальной и цирротически измененной печени. Цитология. 50(3): 228-236.
  • Baidyuk E.V., Shiryaeva A.P., Bezborodkina N.N., Sakuta G.A. 2009. Morphology and function of cultured hepatocytes isolated from rats with experimental toxic hepatitis. Cell and Tissue Biology. 3 (6): 565–572.
    https://doi.org/10.1134/S1990519X09060108
  • Безбородкина Н.Н., Киршина Е.И., Мушинская Е.В., Кудрявцев Б.Н. 2009. Применение реактивов типа Шиффа с различными спектральными характеристиками для определения легкодоступной и труднодоступной фракций гликогена в отдельных гепатоцитах. Цитология. 51 (12): 1025-1035.
  • Безбородкина Н.Н., Вахтина А.А., Байдюк Е.В., Якупова Г.С., Кудрявцев Б.Н. 2009. Взаимосвязь между содержанием гликогена в гепатоцитах и их размером в нормальной и цирротической печени крыс. Цитология. 51 (5): 417-427.
  • Bezborodkina N.N., Shtein G.I., Sivova E.V., Chestnova A.Yu., Kudryavtsev B.N. 2011. Analysis of structure of glycogen in rat hepatocytes using cytochemical and FRET methods. Cell and Tissue Biology. 5 (5): 417–427.
    https://doi.org/10.1134/S1990519X11050038
  • Байдюк Е.В., Биткова Е.А., Безбородкина Н.Н., Карпов А.А., Коршак О.В., Сакута Г.А., Кудрявцев Б.Н. 2012. Гетерогенность кардиомиоцитов левого желудочка сердца крысы. Бюл. эксп. биол. мед. 153 (2): 162-164.
    https://doi.org/10.1007/s10517-012-1675-y
  • Natalia N. Bezborodkina, Sergey V. Okovity, Anna Yu. Chestnova, Boris N. Kudryavtsev.  2013. Hepatocytes of cirrhotic rat liver accumulate glycogen more slowly than normal ones. Hepatol Int. 7:1084-1090.
    https://doi.org/10.1007/s12072-013-9458-8
  • Natalia N. Bezborodkina, Anna Yu. Chestnova, Boris N. Kudryavtsev. 2013. Glycogen metabolism during chronic liver diseases. In: P.L. Weiss and B. D. Faulkner, editors. Glycogen: Structure, Functions in the Body and Role in Disease. NOVA Publishers. 47-79. https://www.worldcat.org/isbn/9781629483955
  • Bezborodkina N.N., Chestnova A.Yu., Okovity S.V., Kudryavtsev B.N. 2014. Activity of glycogen synthase and glycogen phosphorylase in normal and cirrhotic rat liver during glycogen synthesis from glucose or fructose. Exp. Toxicol. Pathol. 66 (2-3): 147-154. https://doi.org/10.1016/j.etp.2013.12.001
  • Chestnova A.Yu., Bezborodkina N.N., Matyukhina N.M., Kudryavtsev B.N. Dynamics of proglycogen and macroglycogen in hepatocytes of normal and cirrhotic rat liver at various stages of glycogenesis. 2015. Cell and Tissue Biology, 9 (2): 133-140.
    https://doi.org/10.1134/S1990519X15020030
  • Bezborodkina N.N., Chestnova A.Yu., Vorobev M.L., Kudryavtsev B.N. Glycogen content in hepatocytes is related with their size in normal rat liver but not in cirrhotic one. Cytometry Part A. 2016, 89(4): 357–364.
    https://doi.org/10.1002/cyto.a.22811
  • Безбородкина Н.Н., Честнова А.Ю., Воробьев М.Л., Кудрявцев Б.Н. 2018. Пространственная структура молекул гликогена. Биохимия. 83 (5): 627-644.
    https://doi.org/10.1134/s0006297918050012
  • Liisa Ailanen, Natalia N. Bezborodkina, Laura Virtanen, Suvi T. Ruohonen, Anastasia V. Malova, Sergey V. Okovityi, Elizaveta Y. Chistyakova, Eriika Savontaus. 2018. Metformin normalizes the structural changes in glycogen preceding prediabetes in mice overexpressing neuropeptide Y in noradrenergic neurons. Pharmacol. Res. Perspect. 6 (2): e00389.
    https://doi.org/10.1002/prp2.389
  • Natalya P. Teryukova, Victoria V. Malkova, Elena I. Sakhenberg, Vadim A. Ivanov, Natalia N. Bezborodkina, Sergei A. Snopov. 2018. On reprogramming of tumor cells metabolism: detection of glycogen in the cell lines of hepatocellular origin with various degrees of dedifferentiation. Cytotechnology. 70 (2): 879-890.
    https://doi.org/10.1007/s10616-018-0200-1
  • Ludmila Chistyakova, Natalia Bezborodkina, Mariia Berdieva, Anton Radaev, Andrew Goodkov. 2020. The nature and features of organization of reserve polysaccharides in three Pelomyxa species (Archamoebea, Pelobiontida). Protoplasma. 257: 1701-1708. https://doi.org/10.1007/s00709-020-01546-5
  • Natalia N Bezborodkina, Andrey V Stepanov, Mikhail L Vorobev, Anna Yu Chestnova, Grigory I Stein, Boris N Kudrayvtsev. 2021. Cytochemical analysis of spatial structure of glycogen molecules in rat hepatocytes. Journal of Molecular Structure. 1228: 129770. https://doi.org/10.1016/j.molstruc.2020.129770
  • Natalia N Bezborodkina, Sergey V. Okovityi and Boris N. Kudrayvtsev. 2021. Postprandial glycogen content is increased in the hepatocytes of human and rat cirrhotic liver. Cells. 10 (5), 976. https://doi.org/10.3390/cells10050976
  • Оковитый С.В., Приходько В.А., Безбородкина Н.Н., Кудрявцев Б.Н. 2022. Гепатопротекторы: руководство для врачей. 2-е изд., перераб. и доп. М.: ГЭОТАР-Медиа, 240 с. ISBN 978-5-9704-6689-6. http://catalog.geotar.ru/lots/NF0021974.html
  • Prikhodko V.A., Bezborodkina N.N., Okovityi S.V. 2022. Pharmacotherapy for Non-Alcoholic Fatty Liver Disease: Emerging Targets and Drug Candidates. Biomedicines. 10, 274. https://doi.org/10.3390/biomedicines10020274
  • Bezborodkina N.N., Stepanov A.V., Vorobev M.L., Stein G.I., Okovityi S.V., Kudrayvtsev B.N. 2022. Dynamics of the glycogen β-particle number in rat hepatocytes during glucose refeeding. International Journal of Molecular Sciences. 23: 9263. https://doi.org/10.3390/ijms23169263
  • Natalia N. Bezborodkina, Vsevolod Ya. Brodsky, Boris N. Kudryavtsev. 2024. The role of cellular polyploidy in the regeneration of the cirrhotic liver in rats and humans. Comparative Cytogenetics 18: 51-57. https://doi.org/10.3897/compcytogen.18.121459

 

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